Across the United States, many women face disparities in wages and employment while providing for their families and balancing child care and other family responsibilities. The growing number of families headed by single mothers exacerbates these issues. In Mississippi, the prevalence of poverty, births to unmarried parents, and the interaction between gender and race disparities makes these challenges particularly detrimental to the state’s families. Attention is being paid on a national level to the gender pay gap and paid family leave. This data brief focuses on the status of women and economic security in Mississippi to inform policy development that addresses the unique challenges of women and families in Mississippi.